Channel: Leah4sci

Category: Education

Tags: protecting groups for alcoholsprotecting groupstbafsilyl etherprotecting groups organic chemistryleah4scitmstms-cltmosalcohol protecting groups

Description: Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism 📺Watch Next: Introduction to Alcohol Properties and Reactions youtu.be/TXJ0ffXyLq0 Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: leah4sci.com/orgo-ebook In this video, you’ll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. You’ll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF. ↪ Links & Resources Mentioned In This Video ↩ ▸Alcohol Reactions Series + Cheat Sheet Leah4sci.com/Alcohol ▸Acetals and Ketals in Organic Chemistry Leah4sci.com/Acetal ▸Grignard Reaction and Mechanism Leah4sci.com/Grignard ▸Polar and Nonpolar Covalent Bonding youtu.be/PlaFSBt5HTU - - - - - - - - - - - - - - - - - - - - - - - - ⏱ In this video: [0:29] Why Protecting Groups are Used [1:43] Ethers as Protecting Groups [2:46] Structure of TMS [3:06] Structure of TBAF [3:32] Protecting Group Full Reaction and Mechanism [5:37] Simplified Reaction and Mechanism [7:30] Another Practice Example - - - - - - - - - - - - - - - - - - - - - - - - Follow along with your semester by using my Orgo Syllabus Companion: leah4sci.com/syllabus For more in-depth review including practice problems and explanations, come join my online membership site, the Organic Chemistry Study Hall: leah4sci.com/join ❓Questions? Ask me here: Leah4sci.com/contact 👩‍🏫 For private online tutoring visit my website: leah4sci.com/organic-chemistry Let’s connect:▸Instagram: instagram.com/leah4sci ▸Facebook: facebook.com/Leah4Sci ▸Twitter: twitter.com/Leah4Sci ▸Pinterest: pinterest.com/leah4sci 🔔 Subscribe to my channel so you don’t miss out on any new videos 🔔 leah4sci.com/youtube 🩺💉 My MCAT YouTube Channel: leah4sci.com/MCATyoutube 💉🩺