Channel: Leah4sci

Category: Education

Tags: grignard to ketonegrignardleah4scigrignard nitrile reactiongrignard reagent with nitrile mechanismgrignard reagent

Description: Leah4sci.com/Grignard presents: Grignard reacting with a nitrile to form a ketone, complete reaction and step by step mechanism 📺Watch Next: Grignard to Alcohol Synthesis Shortcuts youtu.be/sQ8dtuuN1TE Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: leah4sci.com/orgo-ebook Grignard reagents are my go-to for chain elongation reactions in orgo 2. This video takes you through the reaction and mechanism of a grignard attacking a nitrile to form a ketone as well as showing you the steps for hydrolysis of the imine intermediate. You’ll learn the step-by-step mechanism for breaking each of the bonds between the carbon and nitrogen through a sequence of proton transfers and see how a water molecule attacks the iminium ion intermediate to form a new bond to oxygen. You’ll also learn a shortcut for predicting the structure of the final product. ↪ Links & Resources Mentioned In This Video ↩ ▸Grignard Series + Cheat Sheet Leah4sci.com/Grignard ▸Polar and Nonpolar Covalent Bonding youtu.be/PlaFSBt5HTU ▸Functional Groups Guide Leah4sci.com/functional-groups-guide - - - - - - - - - - - - - - - - - - - - - - - - ⏱ In this video: [0:15] Overview of Reaction [0:33] Why a Grignard Attacks a Nitrile [0:50] Mechanism for the Grignard and Nitrile Reaction [1:47] Formation of Imine Intermediate [4:08] Ammonia Leaving Group [5:10] Final Ketone Product [5:53] Shortcut for Predicting Final Product - - - - - - - - - - - - - - - - - - - - - - - - Follow along with your semester by using my Orgo Syllabus Companion: leah4sci.com/syllabus For more in-depth review including practice problems and explanations, come join my online membership site, the Organic Chemistry Study Hall: leah4sci.com/join ❓Questions? Ask me here: Leah4sci.com/contact 👩‍🏫 For private online tutoring visit my website: leah4sci.com/organic-chemistry Let’s connect:▸Instagram: instagram.com/leah4sci ▸Facebook: facebook.com/Leah4Sci ▸Twitter: twitter.com/Leah4Sci ▸Pinterest: pinterest.com/leah4sci 🔔 Subscribe to my channel so you don’t miss out on any new videos 🔔 leah4sci.com/youtube 🩺💉 My MCAT YouTube Channel: leah4sci.com/MCATyoutube 💉🩺