Channel: iBiology

Category: Science & Technology

Tags: meningiomaexperimental cancer therapycdk6cdk4cell cycleabemaciclibbrain tumorcnvbrain cancerdna methylationcyclin dependent kinasecopy number variationgene regulationhistone acetylationusf1

Description: iBiology.org Abrar Choudhury describes how he studied DNA methylation to understand the biology of meningioma and identify a novel candidate therapy. Meningioma is the most common intracranial tumor, with limited treatment options. In order to identify new therapies for meningioma, it is important to understand their underlying biology. In this Share Your Research talk, Dr. Abrar Choudhury describes his thesis research, which began by looking at DNA methylation patterns to better understand gene regulation in meningioma, leading him to identify the cell cycle proteins CDK4 and CDK6 as therapeutic targets. 0:00 - 2:35 Introduction 2:36 - 9:52 Studying DNA methylation to understand meningioma biology 9:53 - 16:20 Studying the altered cell cycle of aggressive meningiomas 16:21 - 22:07 Identifying a new candidate therapy for meningioma 22:07 - 23:06 Conclusion Speaker Biography: Abrar Choudhury completed his PhD in Biomedical Sciences at UCSF, and will receive his MD from UCSF in 2023. He studies the underlying biology of brain tumors with the goal of identifying novel therapeutic targets. twitter.com/abrarc raleighlab.ucsf.edu/raleigh-laboratory Credits: Brittany Anderton (iBiology): Producer Eric Kornblum (iBiology): Videographer and Editor Chris George: Design and Graphics Maggie Hubbard: Design and Graphics