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Waning vaccine efficacy in the UK

Duration: 18:09Views: 474KLikes: 15.4KDate Created: Apr, 2022

Channel: Dr. John Campbell

Category: Education

Tags: human biologydiseasebiologymedical educationphysiologyhealthnursingmedicinehuman bodycampbellnclexpathophysiologynurse education

Description: Beijing, 70 cases since Friday Three P.C.R. tests over five days zero Covid strategy assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1070356/Vaccine-surveillance-report-week-16.pdf Effectiveness against symptomatic disease After 2 doses of the AstraZeneca Against the Omicron variant Starts at 45 to 50% Drops to almost no effect, 25 weeks after the second dose With 2 doses of Pfizer or Moderna Effectiveness dropped from around 65 to 70% Down to around 15% by 25 weeks after the second dose Two to 4 weeks after a booster dose Effectiveness ranges from around 60 to 75% Dropping to almost no effect from 20+ weeks after the booster Effectiveness against hospitalisation Alpha and Delta variants Higher levels of protection against hospitalisation with all vaccines Omicron 18 to 64 year olds All COVID-19 cases admitted via emergency care VE after a booster peaked at 82.4% Dropped to 53.6% by 15+ weeks after the booster Needed oxygen/ventilated VE 97.1% down to 75.9% Also Omicron generally causes milder disease, in particular among younger individuals All individuals who are hospitalised are tested for COVID-19 An increasing proportion of individuals hospitalised with a positive COVID- 19 test are likely to have COVID-19 as an incidental finding rather than the primary reason for admission. All 3 vaccines give similar protection against hospitalisation Effectiveness against mortality Alpha and Delta Over 90% protection against mortality with all 3 vaccines Vaccine effectiveness against mortality with Omicron At 25-plus weeks following the second dose, vaccine effectiveness was around 60%

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